the LRG@ysm seeks to understand and intervene in human degenerative diseases using a wide variety of theoretical and experimental techniques.

In particular, we work to understand protein aggregation diseases from a biophysical perspective. Many of these conditions involve a toxic accumulation of amyloid proteins and plaques over the lifecourse, leading to degenerative dysfunction and death. By combining molecular models of protein folding and aggregation with solution biophysics techniques, we can deduce and modify thermodynamic landscapes that are distinctly pathological in order to mitigate human diseases.

For more information, check out our research interests and publications pages!

PI: Zachary A. Levine, Phd

Zachary (Zach) Levine is currently an Assistant Professor of Pathology at the Yale School of Medicine and the Graduate School at Yale University. His training is in computational biophysics and his interests have recently expanded into solution biophysics techniques in amyloid protein systems. Many of his projects combine atomistic models with solution NMR spectroscopy in order to better understand the physical and thermodynamic determinants of age-related diseases.

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protein folding

We're particularly interested in modeling intrinsically disordered proteins (IDPs) through molecular dynamics (MD) simulations with enhanced-sampling in order to observe both physiological and pathological protein states.

Solution biophysics

Theoretical predictions are then combined with observations from solution NMR spectroscopy, chromatography, and immunoassays in order to iteratively refine models and recapitulate the molecular basis of amyloid diseases.

LRG@YSM IS always searching for enthusiastic and motivated scientists to join our team!

Created in the Fall of 2019, we are currently expanding and are interested in recruiting undergraduate, graduate, and postdoctoral researchers. For more information, please send your CV to:

Recent News

One of our articles was recently featured on the front cover of the Journal of the American Chemical Society (JACS)! Check out more information here.